Artificial Intelligence Non-invasive Methods for Neonatal Jaundice Detection: A Review

Neonatal jaundice is a common and potentially fatal health condition in neonates, especially in low and middle income countries, where it contributes considerably to neonatal morbidity and death. Traditional diagnostic approaches, such as Total Serum Bilirubin (TSB) testing, are invasive and could lead to discomfort, infection risk, and diagnostic delays. As a result, there is a rising interest in non-invasive approaches for detecting jaundice early and accurately.
An in-depth analysis of non-invasive techniques for detecting neonatal jaundice is presented by this review, exploring several AI-driven techniques, such as Machine Learning (ML) and Deep Learning (DL), which have demonstrated the ability to enhance diagnostic accuracy by evaluating complex patterns in neonatal skin color and other relevant features. It is identified that AI models incorporating variants of neural networks achieve an accuracy rate of over 90% in detecting jaundice when compared to traditional methods. Furthermore, satisfactory outcomes in field settings have been demonstrated by mobile-based applications that use smartphone cameras to estimate bilirubin levels, providing a practical alternative for resource-constrained areas. The potential impact of AI-based solutions on reducing neonatal morbidity and mortality is evaluated by this review, with a focus on real-world clinical challenges, highlighting the effectiveness and practicality of AI-based strategies as an assistive tool in revolutionizing neonatal care through early jaundice diagnosis, while also addressing the ethical and practical implications
of integrating these technologies in clinical practice. Future research areas, such as the development of new imaging technologies and the incorporation of wearable sensors for real-time bilirubin monitoring, are recommended by the paper.